beat365体育亚洲官网在线下载 - 歡迎您!


“高屋建瓴AI公开课”第18期:Towards Accurate Biomedical Genomics Anywhere Anytime


报告时间: 2022年6月1日(星期三)19:30-21:00          

腾讯会议: 345-509-513                    

主讲人姓名: 高欣  沙特阿卜杜拉国王科技大学(KAUST)终身正教授、beat365体育亚洲官网在线下载访问讲座教授



报告题目: Towards Accurate Biomedical Genomics Anywhere Anytime

报告摘要:Current genetic diagnosis by next-generation sequencing requires a large investment of resources and offers little point-of-care portability. Furthermore, it is unable to detect many types of genetic variations ¬– including large deletions, duplications, and balanced translocations ¬– that are relevant to human diseases and health.

   Comparing to other sequencing technologies, Nanopore sequencing owns the advantages of point-of-care (i.e., sequencing anywhere anytime), long reads (i.e., assembly-free to detect various genetic variations), and PCR free (i.e., sample preparation is easy). However, its application is severely limited by a number of challenges, including low base-calling accuracy, lack of training data for AI-based methods, and computational burden on reads mapping.

    In this talk, I will first give an overview of the research activities in Structural and Functional Bioinformatics Group. I will then focus on our efforts on developing computational methods to tackle key open problems in Nanopore sequencing. In particular, I will introduce our recent works on developing a collection of computational methods to decode raw electrical current signal sequences into DNA sequences, to simulate raw signals of Nanopore, and to efficiently and accurately align electrical current signal sequences with DNA sequences. I will further introduce their applications in biomedicine and healthcare.